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Michel Kranendonk Selected Research

NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)

1/2016Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
4/2012Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system.
2/2010Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect.
7/2008Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.

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Michel Kranendonk Research Topics

Disease

4Antley-Bixler Syndrome Phenotype
01/2016 - 07/2008
2Neoplasms (Cancer)
01/2016 - 06/2002
1Acute Liver Failure (Fulminant Hepatic Failure)
10/2021
1Chemical and Drug Induced Liver Injury
10/2021
1Carcinogenesis
08/2016
1Congenital Abnormalities (Deformity)
01/2016
1Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
02/2010
1Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
02/2010
1Chromosome Aberrations (Chromosome Abnormalities)
05/2006
1Thyroid Neoplasms (Thyroid Cancer)
06/2002

Drug/Important Bio-Agent (IBA)

4NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)IBA
01/2016 - 07/2008
2Pharmaceutical PreparationsIBA
10/2021 - 01/2016
2DNA (Deoxyribonucleic Acid)IBA
01/2016 - 06/2002
1CytochromesIBA
08/2016
14,6-dinitro-o-cresol (DNOC)IBA
01/2016
1Cytochrome P-450 CYP3AIBA
04/2012
1Flavin Mononucleotide (FMN)IBA
02/2010
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
02/2010
1XenobioticsIBA
07/2008
1Flavin-Adenine Dinucleotide (FAD)IBA
07/2008
1Oxidoreductases (Dehydrogenase)IBA
07/2008
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
07/2008
1EugenolIBA
05/2006
1A-factor (Streptomyces)IBA
06/2002

Therapy/Procedure

1Liver Transplantation
10/2021